New hopes for the treatment of lupus

LUPUS is an autoimmune disease in which the body's immune system cannot distinguish between its own cells and foreign agents, so it mistakenly attacks tissues. And his organs attack. In fact, the attacking molecules called autoantibodies fight against themselves instead of protecting the body (like normal antibodies); In such a situation, there is a flow of inflammations throughout the body, which leads to joint and skin problems, pain, fatigue and even damage to the organs. Lupus patients themselves used to treat this disease. Of course, it should be noted that although the research sample in this experiment was small, it has achieved significant results. Lupus disease treatment method is one of the most promising treatment procedures, with the help of which one can even see successes in the treatment process of some incurable cancers.

BingMag.com New hopes for the treatment of lupus

LUPUS is an autoimmune disease in which the body's immune system cannot distinguish between its own cells and foreign agents, so it mistakenly attacks tissues. And his organs attack. In fact, the attacking molecules called autoantibodies fight against themselves instead of protecting the body (like normal antibodies); In such a situation, there is a flow of inflammations throughout the body, which leads to joint and skin problems, pain, fatigue and even damage to the organs. Lupus patients themselves used to treat this disease. Of course, it should be noted that although the research sample in this experiment was small, it has achieved significant results. Lupus disease treatment method is one of the most promising treatment procedures, with the help of which one can even see successes in the treatment process of some incurable cancers.

Description of lupus disease treatment method

In this experiment Supercharged immune cells were injected into five people as a sample community, and during the treatment period, the effects of recovery from severe lupus were seen in them. In this method, cells that produce antibodies against the body's own tissues were modified. The interesting part is that this treatment, known as CAR-T, has also been successfully tested against some well-known, hard-to-treat cancers. They treated the patient (helper T lymphocyte), which is a key component of the immune system, then turned these cells into killers that effectively target a specific target. In this case, the target is the B lymphocytes (immune cells in healthy people that make antibodies!) that attack their own antibodies in people with lupus.

In general, T cells (T lymphocytes) play an important role in They act as a safety device. As their name suggests, these cells help activate other immune cells by releasing cytokines. It is necessary to know that cytokines are small proteins that change the behavior of target cells that have cytokine receptors. Using genetic engineering techniques, researchers isolated T lymphocytes in order to detect a protein called CD19. CD19 is a protein that appears on the surface of B lymphocytes that produce autoantibodies.

B cells are lymphocytes in the body's immune system that produce antibodies against viruses. These lymphocytes play a role in humoral immunity, which, together with cellular immunity, form a specific defense mechanism. It is interesting to know that these lymphocytes act specifically, that is, they recognize and destroy a certain type of foreign agent.

In this regard, scientists use more numbers of modified T lymphocytes until a sufficient dose ( About 50 to 100 million cells (depending on the patient's weight) were grown. During this process, patients were injected with modified T lymphocytes to seek out and destroy their defective B lymphocytes. The successful part of the story is that after about 100 days, the patients started making new B lymphocytes that were free of the harmful autoantibodies, in fact, the autoantibodies had disappeared altogether!

What is Lupus? Is it a disease?

As you know, lupus is a lifelong disease that has no cure, and according to the Lupus Foundation of America, this disease affects about 1.5 million people in the United States and 5 million people worldwide. It is impressive that many of them are young women. In this regard, most patients use immunosuppressive drugs to control the inflammation of the organs, while most of these drugs make the body more vulnerable to various infections and often have unpleasant side effects. Of course, it is necessary to emphasize that new antibody drugs, whose purpose is to protect the body from attacking itself, can help some patients, but it certainly does not include the condition of all people, and more research is still needed with a larger statistical population.

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