Yes, it is possible to get mono (mononucleosis) more than once. Mono is caused by the Epstein-Barr virus (EBV), and once a person is infected with EBV, the virus remains in their body for life. While most people develop immunity to the virus after their first infection, it is still possible for the virus to reactivate and cause symptoms again in some individuals. Additionally, there are other strains of the virus that can cause mono-like symptoms, so it is possible to be infected with a different strain after recovering from a previous infection.
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